References and Testimonials
"We are very happy with your service. I have been recommending your company to many of my colleagues. Thanks so much for you great work!"
"Blue Sky exceeded the expectation in having the prep ready accompanied by a data report. The tight communication and follow-through along with prep delivery are very much appreciated efforts, demonstrating (Blue Sky’s) focus on customer service."
"My group started working with Blue Sky Biotech around October 2008. Since then, they have produced more than 90 recombinant proteins for us. We initially sent them E. coli cell paste expressing our protein of interest for final purification. We knew that most of these proteins were difficult to work with, in that they would end up in inclusion bodies and need to be ‘re-folded’. The Blue Sky team—with their experience in protein purification and re-folding—were able to quickly optimize conditions for several of the proteins and send us the purified material. For newer targets, we often just send them the amino acid sequence, and have them do everything: gene synthesis, codon optimization, expression and purification."
"The quality of the data and the final purified product has met our requirements. Blue Sky has been, and continues to be very successful at providing us with critical reagents, which allow progression of our programs."
"I have finally tested the sample that you sent to me and I was astounded by the amount of expression you were able to achieve. I really hope we can scale this up because you guys achieved great results."
"We are very satisfied with the gene synthesis and protein services (strain creation, expression scout, pilot expression) provided by Blue Sky BioServices. Everything went really fast and smooth. The soluble protein recovery was outstanding, beyond our best expectations. Besides, customer services and scientific staff support was very efficient and helpful in every step of our project. We definitively intend to use Blue Sky services again and highly recommend to everyone who needs fast and reliable recombinant protein production."
Tulio Marcos Santos, MS, Ph.D.
"The overall focus of my lab is to understand the nature of the molecular defect in T-cells which results in the development of autoimmunity. Our research is based on the observation that autoreactive T cells, that is, T cells programmed to attack the body's own cells and tissues, are more sensitive to the effects of TNF-alpha (TNF-a), a cytokine that influences the immune system. We have worked with Blue Sky Biotech, a Worcester-based CRO, who has helped us develop several recombinant forms of TNF-a and its receptors. The Blue Sky team has an in-depth understanding of protein expression and purification, which is invaluable when it comes to working with recombinant molecules. Their ability to trouble-shoot various aspects of the process is very helpful; it allows us focus on the down-stream work beyond protein production."
Dr. Denise Faustman, M.D., Ph.D.
"While developing our technology and extending the applications of the device, we required a diverse set of microbiological and biochemical analyses to demonstrate efficacy and investigate the mechanism of action of our laser. We looked for a collaborator, which had expertise in culturing a wide range of organisms, including relevant fungi such as Trichophyton rubrum, methicillin-resistant Staphylococcus aureus (MRSA), and mammalian cells such as adipocytes. Blue Sky's team of skilled scientists enabled us to produce an unbiased data set demonstrating our lasers' effectiveness on reducing viability of the organisms of clinical interest. Further, Blue Sky's fluency in biochemical assays allowed us to explore the mechanism of action in detail. These experiments and body of data could not have been generated without this collaboration."
Dr. Eric Bornstein, DMD
Bornstein, Eric, Scott Gridley, and Paul Wengender. 2010. Photo-damage to multi-drug resistant Gm-positive and Gram-negative bacteria potentiates B-lactam, macrolide, ketolide and fluoroquinolone antibiotics. Photochemistry and Photobiology accepted, in press.
Bornstein, Eric, William Hermans, Scott Gridley, and Jeffrey Manni. 2009. Near-infrared Photoinactivation of Bacteria and Fungi at Physiologic Temperatures. Photochemistry and Photobiology 85, no. 6: 1364–74, http://www3.interscience.wiley.com/journal/122578313/abstract (accessed May 10, 2010).