Blue Sky’s diverse small molecules library was designed to include compounds with drug-like physiochemical properties for all major of therapeutic target classes. In addition, the compounds were also selected based on synthetic feasibility and a high probability of hit rate, reducing the cost to screen and increasing the likelihood of running a successful hit-to-lead program. We use Core Informatics LIMS to manage primary and secondary screening data and compound inventory. The inventory capabilities also allow us to archive compound libraries for clients. Blue Sky BioServices also works closely with clients to ensure a seamless transfer of data to client databases.